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New Technique Lets Scientists See Through Whole Organisms

by Michael Keller

Seeing is believing when it comes to understanding how organisms work. For biologists trying to learn about what’s going on inside a body, one of the biggest obstacles is not being able to put their eyeballs on a part or system without other objects getting in the way. The answer is usually going in with one invasive tool or another, which ends up damaging or destroying the thing they’re trying to investigate. 

Now California Institute of Technology scientists say they have improved upon a solution to clearing up the picture. The technique builds on work that garnered widespread attention last year. In that effort, assistant professor of biology Viviana Gradinaru and her team used detergent and a polymer to make a rodent brain transparent for study in unprecedented detail. 

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